Search results for " models of human"
showing 2 items of 2 documents
Local Application of Leptin Antagonist Attenuates Angiotensin II–Induced Ascending Aortic Aneurysm and Cardiac Remodeling
2016
Background Ascending thoracic aortic aneurysm ( ATAA ) is driven by angiotensin II (Ang II ) and contributes to the development of left ventricular ( LV ) remodeling through aortoventricular coupling. We previously showed that locally available leptin augments Ang II ‐induced abdominal aortic aneurysms in apolipoprotein E–deficient mice. We hypothesized that locally synthesized leptin mediates Ang II ‐induced ATAA . Methods and Results Following demonstration of leptin synthesis in samples of human ATAA associated with different etiologies, we modeled in situ leptin expression in apolipoprotein E–deficient mice by applying exogenous leptin on the surface of the ascending aorta. This treatm…
L'Ecuba euripidea: dramma della violenza sugli inermi
2010
This paper focuses on ‘violence on unarmed people’ as the unifying theme that underlies the structure of the tragedy with an anthropopoietic function, what means to build up, by contrast, models of human and humanity.. All the three forms of violence against unarmed people, which can be singled out in the tragedy, are analyzed. The first is the sacred violence of Polyxena’s sacrifice, which is represented as an unnecessary and avoidable killing, due to the excessive power of the winners Greeks on losers barbarians. The second is the criminal violence upon Polydorus, motivated by greed for gold but also due to the impunity in a destructive war. The third is the ‘maenadic’ violence by which H…